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(iii) terminal differentiation, involving expression of genes and transcriptional factors such as CCAAT/enhancer-binding proteins (C/EBPs) family and peroxisome proliferator-activated receptor–γ (PPARγ) – and a dramatic increase in lipogenesis and induction of lipogenic genes such as acetyl CoA carboxylase (ACC), Fatty acid synthase (FAS) and adipocyte fatty acid binding protein (aP2) (Lefterova and Lazar, 2009